515 N. Mound St., 936/569-7292, Tours Tues-Fri, 1-4; Sat, 10-4. www.olduniversitybuilding.com

Built in 1858, it is the only remaining building of the Nacogdoches University chartered in 1845 by the Republic of Texas. It was used as a hospital during the Civil War. The building is furnished with period pieces, mostly Victorian.