515 N. Mound St., 936/569-7292, Tours Tues-Fri, 1-4; Sat, 10-4. www.olduniversitybuilding.com

Built in 1858, it is the only remaining building of the Nacogdoches University chartered in 1845 by the Republic of Texas to fulfill settlers’ideals for higher education. It was used as a hospital during the Civil War. The building is furnished with period pieces.